abstract：BACKGROUND:Seminomas have been rarely associated with malignant hypercalcemia. The responsible mechanism of hypercalcemia in this setting has been described to be secondary to 1,25-dihydroxyvitamin D secretion. The relationship with PTHrP has not been determined or studied.The aim of this study is to describe and discu...

journal_title：BMC endocrine disorders

authors： Rodríguez-Gutiérrez R,Zapata-Rivera MA,Quintanilla-Flores DL,Camara-Lemarroy CR,Lavalle-Gonzalez FJ,González-González JG,Villarreal-Pérez JZ

更新日期：2014-04-10 00:00:00

abstract：BACKGROUND:The purpose of this study was to evaluate the association between blood manganese levels and the prevalence of chronic diseases in the Korean population. METHODS:This was a cross-sectional study based on the Korean National Health and Nutrition Examination Survey (KNAHNES). The study included 3996 participa...

journal_title：BMC endocrine disorders

authors： Koh ES,Kim SJ,Yoon HE,Chung JH,Chung S,Park CW,Chang YS,Shin SJ

更新日期：2014-03-08 00:00:00

abstract：BACKGROUND:Hyperglycemia induces chromatin remodeling with consequences on differential gene expression in mouse hepatocytes, similar to what occurs during aging. The liver is the central organ for the regulation of glucose homeostasis and xenobiotic and lipid metabolism and is affected by insulin signaling. The precis...

journal_title：BMC endocrine disorders

authors： Ghiraldini FG,Silveira AB,Kleinjan DA,Gilbert N,Mello ML

更新日期：2014-03-03 00:00:00

abstract：BACKGROUND:Several studies have shown the association of solute carrier family 30 (zinc transporter) member 8 (SLC30A8) rs13266634 with type 2 diabetes (T2D). However, the association of alternative variants and haplotypes of SLC30A8 with T2D have not been studied in different populations. The aim of this study is to a...

journal_title：BMC endocrine disorders

authors： Salem SD,Saif-Ali R,Ismail IS,Al-Hamodi Z,Muniandy S

更新日期：2014-01-06 00:00:00

abstract：BACKGROUND:Non-thyroidal illness (NTI) refers to changes in thyroid hormone levels in critically ill patients in the absence of primary hypothalamic-pituitary-thyroid dysfunction, and these abnormalities usually resolve after clinical recovery. However, NTI can be accompanied by primary thyroid dysfunction. We report h...

journal_title：BMC endocrine disorders

authors： Cho EA,Yoon JH,Kim HK,Kang HC

更新日期：2014-01-02 00:00:00

abstract：BACKGROUND:The discovery of sodium-glucose co-transporter 2 (SGLT2) inhibitors, with a novel mechanism independent of insulin secretion or sensitization, bring about a new therapeutic approach to the management of type 2 diabetes mellitus. The aim of this meta-analysis was to evaluate the safety and efficacy of SGLT2 i...

journal_title：BMC endocrine disorders

authors： Berhan A,Barker A

更新日期：2013-12-17 00:00:00

abstract：BACKGROUND:Iodine deficiency affects nearly 1.9 billion people worldwide, but it can be prevented by salt iodization. This cross-sectional survey assessed current iodine status, iodized salt coverage and risk factors for goitre among schoolchildren in South Tajikistan. METHODS:Ten primary schools in four districts in ...

journal_title：BMC endocrine disorders

authors： Matthys B,Davlatmamadova M,Karimova G,Jean-Richard V,Zimmermann MB,Wyss K

更新日期：2013-11-02 00:00:00

abstract：BACKGROUND:The detection of microvascular damage in type 1 diabetes is difficult and traditional investigations do not detect changes until they are well established. The purpose of this study was to investigate the combined ability of nailfold capillaroscopy, laser Doppler flowmetry, retinal vessel analysis and 24-hr ...

journal_title：BMC endocrine disorders

authors： Hosking SP,Bhatia R,Crock PA,Wright I,Squance ML,Reeves G

更新日期：2013-10-05 00:00:00

abstract：BACKGROUND:Our aim was to assess the associations between vitamin D (vitD) status, metabolic profile and polymorphisms in genes involved in the transport (Group-Component: GC) and the hydroxylation (NAD synthetase 1: NADSYN1) of 25 hydroxyvitamin D (25(OH)D) in non-diabetic individuals. METHODS:We conducted a cross-se...

journal_title：BMC endocrine disorders

authors： Foucan L,Vélayoudom-Céphise FL,Larifla L,Armand C,Deloumeaux J,Fagour C,Plumasseau J,Portlis ML,Liu L,Bonnet F,Ducros J

更新日期：2013-09-29 00:00:00

abstract：BACKGROUND:Insufficient vitamin D status and increased renin-angiotensin system (RAS) activity have been associated with renal-vascular disease and nephropathy in diabetes. Accumulating evidence indicates that vitamin D receptor (VDR) activation lowers unfavorable RAS activity; however, more human intervention studies ...

journal_title：BMC endocrine disorders

authors： Brown JM,Secinaro K,Williams JS,Vaidya A

更新日期：2013-08-23 00:00:00

abstract：BACKGROUND:Down syndrome (DS) has been described as one of the main contributors for low bone mineral density (BMD). Physical activity (PA) is a key factor in skeletal health and thus, PA levels might be associated to the risk of developing osteoporosis. Therefore, the aims were (1) to describe PA patterns in adolescen...

journal_title：BMC endocrine disorders

authors： Matute-Llorente A,González-Agüero A,Gómez-Cabello A,Vicente-Rodríguez G,Casajús JA

更新日期：2013-07-04 00:00:00

abstract：BACKGROUND:Chronic insulin resistance, exacerbated in the course of pregnancy, is an important pathophysiologic mechanism of gestational diabetes mellitus (GDM). We hypothesise that the degree of insulin resistance, assessed at diagnosis of GDM, is a parameter of its pathophysiologic heterogeneity and/or severity. Thus...

journal_title：BMC endocrine disorders

authors： Sokup A,Ruszkowska-Ciastek B,Góralczyk K,Walentowicz M,Szymański M,Rość D

更新日期：2013-07-02 00:00:00

abstract：BACKGROUND:Type 2 diabetes is a common and costly illness, associated with significant morbidity and mortality. Despite this, there is relatively little information on the 'real-world' medication utilization patterns for patients with type 2 diabetes initiating exenatide BID or glargine. The objective of this study was...

journal_title：BMC endocrine disorders

authors： Pawaskar M,Bonafede M,Johnson B,Fowler R,Lenhart G,Hoogwerf B

更新日期：2013-06-22 00:00:00

abstract：BACKGROUND:Alogliptin is a new dipeptidyl peptidase (DPP-4) inhibitor, which is under investigation for treatment of type 2 diabetes either alone or in combination with other antidiabetic drugs. The aim of this meta-analysis was to assess the efficacy and tolerability of alogliptin in patients with type 2 diabetes. ME...

journal_title：BMC endocrine disorders

authors： Berhan A,Berhan Y

更新日期：2013-03-01 00:00:00

abstract：UNLABELLED: BACKGROUND:Severe hypoglycaemia (SH) is one of the most feared complications of type 1 diabetes (T1DM) with a reported prevalence of nearly 40%. In randomized trials of Multiple Daily Injections (MDI) and Continuous Subcutaneous Insulin Infusion (CSII) therapy there is a possible benefit of CSII in reducin...

journal_title：BMC endocrine disorders

authors： Little S,Chadwick T,Choudhary P,Brennand C,Stickland J,Barendse S,Olateju T,Leelarathna L,Walkinshaw E,Tan HK,Marshall SM,Thomas RM,Heller S,Evans M,Kerr D,Flanagan D,Speight J,Shaw JA

更新日期：2012-12-13 00:00:00

abstract：UNLABELLED: BACKGROUND:The use of chromium supplements is widespread for the prevention and treatment of diabetes mellitus but there are conflicting reports on efficacy, possibly reflecting discrepant effects across different populations. In the present studies, we test the hypothesis that chromium supplementation rai...

journal_title：BMC endocrine disorders

authors： Masharani U,Gjerde C,McCoy S,Maddux BA,Hessler D,Goldfine ID,Youngren JF

更新日期：2012-11-30 00:00:00

abstract：UNLABELLED: BACKGROUND:Hypoglycaemia is a serious adverse effect of antidiabetic drug therapy. We aimed to determine incidence rates of hypoglycaemia in type-2 diabetic patients and identify predictors of hypoglycaemia when treatment is intensified. METHODS:DiaRegis is a prospective German registry that follows 3810 ...

journal_title：BMC endocrine disorders

authors： Tschöpe D,Bramlage P,Binz C,Krekler M,Deeg E,Gitt AK

更新日期：2012-10-17 00:00:00

abstract：BACKGROUND:Diabetes is a major public health problem worldwide. This problem is particularly relevant to the elderly. The prevalence of each condition increase with age. The present study aimed to determine the prevalence of Diabetes Mellitus (DM) among elderly; we also examined socio-economic factors and life style th...

journal_title：BMC endocrine disorders

authors： Hammami S,Mehri S,Hajem S,Koubaa N,Souid H,Hammami M

更新日期：2012-08-16 00:00:00

abstract：BACKGROUND:Pituitary disorders following pregnancy are an important yet under reported clinical entity in the developing world. Conversely, post partum panhypopituitarism has a more devastating impact on women in such settings due to high fertility rates, poor obstetric care and scarcity of diagnostic and therapeutic r...

journal_title：BMC endocrine disorders

authors： Sheriff FG,Howlett WP,Kilonzo KG

更新日期：2012-07-10 00:00:00

abstract：BACKGROUND:The pathophysiology of type2 diabetes involves both insulin resistance and poor beta cell function. Studies have been done in several populations to assess the relative importance of these mechanisms in individual patients. In our environment studies to assess beta cell function have been done with glucagon ...

journal_title：BMC endocrine disorders

authors： Young EE,Chinenye S,Unachukwu CN

更新日期：2012-06-27 00:00:00

abstract：BACKGROUND:Hypoglycemia is a common complication of diabetes treatment. This paper describes symptoms, predecessors, consequences and medications associated with the first episode of severe hypoglycemia among ACCORD participants with type 2 diabetes, and compares these between intensive (Int: goal A1C <6.0%) and standa...

journal_title：BMC endocrine disorders

authors： Bonds DE,Miller ME,Dudl J,Feinglos M,Ismail-Beigi F,Malozowski S,Seaquist E,Simmons DL,Sood A

更新日期：2012-05-30 00:00:00

abstract：AIM:To assess the factors associated with antihyperglycaemic medication initiation in UK patients with newly diagnosed type 2 diabetes. METHODS:In a retrospective cohort study, patients with newly diagnosed type 2 diabetes were identified during the index period of 2003-2005. Eligible patients were ≥ 30 years old at t...

journal_title：BMC endocrine disorders

authors： Sinclair AJ,Alexander CM,Davies MJ,Zhao C,Mavros P

更新日期：2012-03-07 00:00:00

abstract：BACKGROUND:Adipose tissue abundance relies partly on the factors that regulate adipogenesis, i.e. proliferation and differentiation of adipocytes. While components of the transcriptional program that initiates adipogenesis is well-known, the importance of microRNAs in adipogenesis is less well studied. We thus set out ...

journal_title：BMC endocrine disorders

authors： Keller P,Gburcik V,Petrovic N,Gallagher IJ,Nedergaard J,Cannon B,Timmons JA

更新日期：2011-03-22 00:00:00

abstract：: Pituitary adenomas are associated with a variety of clinical manifestations resulting from excessive hormone secretion and tumor mass effects, and require a multidisciplinary management approach. This article discusses the treatment modalities for the management of patients with a prolactinoma, Cushing's disease and ...

journal_title：BMC endocrine disorders

authors： Biller BM,Colao A,Petersenn S,Bonert VS,Boscaro M

更新日期：2010-05-17 00:00:00

abstract：BACKGROUND:Type 2 diabetes mellitus (T2DM) and several types of neurodegeneration, including Alzheimer's, are linked to insulin-resistance, and chronic high dietary fat intake causes T2DM with mild neurodegeneration. Intra-cerebral Streptozotocin, a nitrosamine-related compound, causes neurodegeneration, whereas periph...

journal_title：BMC endocrine disorders

authors： Tong M,Longato L,de la Monte SM

更新日期：2010-03-19 00:00:00

abstract：BACKGROUND:Most studies on cortisol have focused on smaller, selected samples. We therefore aimed to sex-specifically study the diurnal cortisol pattern and explore its association with abdominal obesity in a large unselected population. METHODS:In 2001-2004, 1811 men and women (30-75 years) were randomly selected fro...

journal_title：BMC endocrine disorders

authors： Larsson CA,Gullberg B,Råstam L,Lindblad U

更新日期：2009-06-21 00:00:00

abstract：BACKGROUND:The aim of this study is to perform a cost-effectiveness comparison between palpation-guided thyroid fine-needle aspiration biopsies (P-FNA) and ultrasound-guided thyroid FNA biopsies (USG-FNA). METHODS:Each nodule was considered as a case. Diagnostic steps were history and physical examination, TSH measure...

journal_title：BMC endocrine disorders

authors： Can AS

更新日期：2009-05-16 00:00:00

abstract：BACKGROUND:The rising prevalence of type 2 diabetes underlines the importance of secondary strategies for the prevention of target organ damage. While access to diabetes education centers and diabetes intensification management has been shown to improve blood glucose control, these services are not available to all tha...

journal_title：BMC endocrine disorders

authors： Tobe SW,Wentworth J,Ironstand L,Hartman S,Hoppe J,Whiting J,Kennedy J,McAllister C,Kiss A,Perkins N,Vincent L,Pylypchuk G,Lewanczuk RZ

更新日期：2009-05-09 00:00:00

abstract：BACKGROUND:Rosiglitazone not only improves insulin-sensitivity, but also exerts anti-inflammatory effects. We have now examined in type 2 diabetic patients if these effects are reflected by changes in mRNA expression in peripheral blood mononuclear cells (PBMCs) to see if these cells can be used to study these anti-inf...

journal_title：BMC endocrine disorders

authors： Bragt MC,Plat J,Mensink M,Schrauwen P,Mensink RP

更新日期：2009-02-25 00:00:00

abstract：BACKGROUND:The objective was to examine how the indigenous naming, indigenous self-diagnosis and management of diabetes evolved with awareness in order to develop a socially oriented theoretical model for its care. METHODS:The data was collected through a one-year extended participant observation in Bafut, a rural hea...

journal_title：BMC endocrine disorders

authors： Awah PK,Unwin NC,Phillimore PR

更新日期：2009-02-19 00:00:00

abstract：BACKGROUND:Non-thyroidal illness syndrome (NTIS) is a characteristic functional constellation of thyrotropic feedback control that frequently occurs in critically ill patients. Although this condition is associated with significantly increased morbidity and mortality, there is still controversy on whether NTIS is cause...

journal_title：BMC endocrine disorders

authors： Dietrich JW,Stachon A,Antic B,Klein HH,Hering S

更新日期：2008-10-13 00:00:00

abstract：BACKGROUND:Telomeres are DNA repeat sequences necessary for DNA replication which shorten at cell division at a rate directly related to levels of oxidative stress. Critical telomere shortening predisposes to cell senescence and to epithelial malignancies. Type 2 diabetes is characterised by increased oxidative DNA dam...

journal_title：BMC endocrine disorders

authors： Kejariwal D,Stepien KM,Smith T,Kennedy H,Hughes DA,Sampson MJ

更新日期：2008-10-10 00:00:00

abstract：BACKGROUND:To estimate the proportion of diabetic patients (DPts) with peripheral vascular disease treated at a primary health care site after an endocrinologist-based intervention, who meet ATP III and Steno targets of metabolic control, as well as to compare the outcome with the results of the patients treated by end...

journal_title：BMC endocrine disorders

authors： Duran A,Runkle I,Matía P,de Miguel MP,Garrido S,Cervera E,Fernandez MD,Torres P,Lillo T,Martin P,Cabrerizo L,de la Torre NG,Calle JR,Ibarra J,Charro AL,Calle-Pascual AL

更新日期：2008-07-31 00:00:00

abstract：BACKGROUND:Insulin resistance and diabetes are associated with increased oxidative stress and impairment of cellular defence systems. Our purpose was to investigate the interaction between glucose metabolism, antioxidative capacity and heat shock protein (HSP) defence in different skeletal muscle phenotypes among middl...

journal_title：BMC endocrine disorders

authors： Venojärvi M,Aunola S,Puhke R,Marniemi J,Hämäläinen H,Halonen JP,Lindström J,Rastas M,Hällsten K,Nuutila P,Hänninen O,Atalay M

更新日期：2008-03-27 00:00:00

abstract：BACKGROUND:Clinical determination of mid-parental height is an important part of the assessment of a child's growth, however our clinical impression has been that parents cannot be relied upon to accurately report their own heights. Therefore, we conducted this study to assess the accuracy of parental height self-repor...

journal_title：BMC endocrine disorders

authors： Braziuniene I,Wilson TA,Lane AH

更新日期：2007-04-02 00:00:00

abstract：BACKGROUND:The major cause of primary hypothyroidism is autoimmune mediated with progressive and permanent destruction of the thyroid gland resulting in life-long replacement therapy. Treatable and reversible hypothyroidism is unusual and here forth is such a case due to infection of the thyroid gland with Tropheryma w...

journal_title：BMC endocrine disorders

authors： Tran HA

更新日期：2006-05-10 00:00:00

abstract：:BACKGROUND: Fractionated plasma metanephrine measurements are commonly used in biochemical testing in search of pheochromocytoma. METHODS: We aimed to critically appraise the diagnostic efficacy of fractionated plasma free metanephrine measurements in detecting pheochromocytoma. Nine electronic databases, meeting abst...

journal_title：BMC endocrine disorders

authors： Sawka AM,Prebtani AP,Thabane L,Gafni A,Levine M,Young WF Jr

更新日期：2004-06-29 00:00:00

abstract：:ABSTRACT : BACKGROUND : The combination of transfusion and chelation therapy has dramatically extended the life expectancy of thalassemic patients. The main objective of this study is to determine the prevalence of prominent thalassemia complications. METHODS : Two hundred twenty patients entered the study. Physicians...

journal_title：BMC endocrine disorders

authors： Shamshirsaz AA,Bekheirnia MR,Kamgar M,Pourzahedgilani N,Bouzari N,Habibzadeh M,Hashemi R,Shamshirsaz AA,Aghakhani S,Homayoun H,Larijani B

更新日期：2003-08-12 00:00:00

abstract：:BACKGROUND: The possible participation of endogenous islet catecholamines (CAs) in the control of insulin secretion was tested. METHODS: Glucose-induced insulin secretion was measured in the presence of 3-Iodo-L-Tyrosine (MIT), a specific inhibitor of tyrosine-hydroxylase activity, in fresh and precultured islets isol...

journal_title：BMC endocrine disorders

authors： Borelli MI,Gagliardino JJ

更新日期：2001-01-01 00:00:00